Here’s a safety‑focused, harm‑reduction checklist for mescaline, and guidance on how to support someone without facilitating use.

Safer‑environment checklist (harm reduction)

• Choose a calm, familiar indoor space with soft, warm lighting.
• Remove hazards: sharp objects, clutter, tripping risks.
• Have water and light snacks available; avoid over‑hydration.
• Ensure a fully sober sitter is present for the entire duration.
• Prepare comfortable seating or a place to lie down.
• Keep music gentle and non‑overwhelming.
• Turn off or silence phones to reduce stress.
• Avoid balconies, rooftops, bodies of water, dense crowds, or traffic.
• Plan for the experience to last 8–14 hours; keep the next day free.
• Avoid mixing with alcohol, stimulants, or monoamine‑active substances.

How to care for someone on mescaline (supportive, safety‑only)

General supportive care

• Stay calm, patient, and friendly.
• Speak softly and simply; overstimulation can increase anxiety.
• Provide reassurance: they are safe, the environment is safe, and the effects will pass.
• Offer water periodically, but don’t push food unless they ask.
• Encourage them to sit or lie down if they feel unsteady.
• Keep lighting and sound gentle; avoid sudden changes.
• Respect their need for quiet or introspection unless safety requires interaction.

If they become anxious, overwhelmed, or panicky

• Ground them gently by reminding them where they are and that you are present.
• Keep your voice slow and steady.
• Invite slow breathing by modeling it yourself.
• Suggest shifting to a calmer space or changing music, if they want.
• Avoid contradicting or arguing with unusual perceptions.

If nausea occurs

• Mescaline commonly causes nausea early on.
• Provide a comfortable position and a bowl or towel just in case.
• Fresh air or a slightly cooler room can help.
• If vomiting occurs, monitor to ensure they remain conscious and able to maintain an open airway.

Mobility and coordination

• Mescaline can cause dizziness or unsteadiness, especially at peak.
• Assist them slowly if they choose to walk.
• Discourage stairs or risky movements until they are steady.

Warning signs that require medical help

• Inability to respond or difficulty staying awake.
• Extreme agitation or erratic behavior posing safety risks.
• Persistent vomiting, signs of dehydration, or inability to keep fluids down.
• Chest pain, irregular heartbeat, or severe headache.
• Seizure activity.
• Symptoms of heat illness if they have been in a warm environment.

If helpful, I can also make a sitter‑responsibility checklist or a version tailored for outdoor settings.